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Measuring the Burden of RSV Among Young Children in Primary Care: Results of the RSV ComNet Pilot in Italy and the Netherlands

JJGT van Summeren1, C. Rizzo2, M. Hooiveld1, J. Korevaar1, M. Dückers1, J. Hendriksen1, S. Caini1, M. Bangert3, C. Demont3, A. Meijer4, E. Pandolfi2, J. Paget1

1Nivel, Netherlands Institute for Health Services Research, Utrecht, Netherlands; 2Ospedale Pediatrica Bambino Gesù, Rome, Italy; 3Sanofi Pasteur, Lyon, France; 4National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands

Despite new developments in the prevention of respiratory syncytial virus, there is a lack of knowledge on the burden of this disease in young children in primary care.

The objective of this study was to develop and evaluate a study protocol to measure the burden of respiratory syncytial virus in children age <5 years in primary care.

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Figure 1
US Safety Overview
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Figure 1 Tap to zoom in (best viewed in landscape mode)

PedsQL, pediatric quality of life inventory; RSV, respiratory syncytial virus; RT-PCR, reverse transcriptase-polymerase chain reaction

  • Age <5 years
  • Italy:
    • Consultation to the pediatrician with ARI symptoms
  • Netherlands:
    • Consultation to the general practitioner with ARI or ILI symptoms (sentinel influenza surveillance)
  • Lab-confirmed RSV (RT-PCR)

ARI, acute respiratory infection; ILI, influenza-like illness; RSV, respiratory syncytial virus; RT-PCR, reverse transcriptase-polymerase chain reaction

  • At Day 14:
    • Medical history
    • Healthcare use for RSV
    • Days of illness
    • Societal impact
    • Current health status
  • At Day 30:
    • PedsQL questionnaire

PedsQL, pediatric quality of life inventory; RSV, respiratory syncytial virus

Table 1
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IQR, interquartile range

  • Study planned in Italy, Netherlands, and the UK
  • Improved study protocol with ‘lessons learned’
  • Measure RSV burden at individual patient level and population level

RSV, respiratory syncytial virus

  • It is feasible to implement the RSV ComNet study protocol via a network of pediatricians and via the routine influenza surveillance network of general practitioners
  • Clinical burden, healthcare utilization, and societal impact of RSV at an individual patient level can be measured in a primary care setting
  • Measuring quality of life (Day-30 questionnaire) is challenging in very young children
  • Day-30 questionnaire can be improved by measuring healthcare utilization, societal impact, and complications related to RSV

RSV, respiratory syncytial virus

This study was funded with a research grant – Sanofi Pasteur and Astra Zeneca.

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